The long read sequencing market in North America is expected to grow from US$ 570.24 million in 2021 to US$ 2,254.97 million by 2028; it is estimated to grow at a CAGR of 21.7% from 2021 to 2028.

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North America Long Read Sequencing Market Overview

Five years ago, genomic sequencing was primarily confined to research laboratories. Today, it is rapidly being integrated into clinical practice. Over the next five years, healthcare systems are expected to generate genomic data from more than 60 million patients. This shift is being propelled by substantial government investments—exceeding USD 4 billion across at least 14 countries—which support national genomic medicine initiatives. These efforts aim to drive transformative change in real-world settings, overcome implementation barriers, and generate evidence for broader adoption, thereby accelerating market growth.

North America Long Read Sequencing Market Introduction –  

North America represents the largest market for long-read sequencing, led by the United States and followed by Canada. This growth is fueled by rising demand for gene synthesis technologies among biopharmaceutical and biotechnology companies, significant R&D activities by academic and research institutions, and strong involvement from key industry players. The region also benefits from widespread adoption of advanced healthcare technologies, government and private sector initiatives to advance precision medicine, and substantial funding for genomic research—all of which are driving revenue growth in the North America Long Read Sequencing Market.

The COVID-19 pandemic further amplified the region's focus on genomic sequencing. The U.S., one of the most affected countries, has witnessed significant changes across its healthcare landscape. In response, researchers and scientists collaborated to expand genomic sequencing efforts, sharing data to enhance disease diagnosis, monitor virus mutations, and inform public health responses. Although the U.S. initially lagged behind—ranking 43rd globally by sequencing just 3% of COVID-19 samples according to the GISAID Initiative—efforts have since intensified.

In April 2020, Genome Canada launched the Canadian COVID Genomics Network (CanCOGeN), a USD 40 million initiative aimed at scaling genome-based research. This program brought together Genome Canada, regional genome centers, sequencing facilities via CGEn, public health labs, universities, hospitals, and private sector partners to expand genomic surveillance nationally and globally.

Similarly, in the U.S., Pacific Biosciences of California, Inc. partnered with Labcorp in April 2020 to develop a high-throughput assay for sequencing the complete genome of thousands of SARS-CoV-2 samples using the Sequel II system.

These developments have significantly boosted demand for long-read sequencing technologies in North America and are expected to continue driving market growth in the years ahead.

North America Long Read Sequencing Market Segmentation

North America Long Read Sequencing Market -By Technology

  • Single-Molecule Real-Time Sequencing (SMRT)
  • Nanopore Sequencing
  • Loop Genomics Long-Read Sequencing

North America Long Read Sequencing Market -By Product

  • Instruments
  • Consumables
  • Services

North America Long Read Sequencing Market -By Application

  • Identification and fine mapping of structural variation
  • Tandem Repeat Sequencing
  • Pseudogene discrimination
  • Resolving allele phasing
  • Reproductive genomics
  • Cancer
  • Viral and Microbial Sequencing
  • Others

North America Long Read Sequencing Market -By Workflow

  • Pre-sequencing
  • Sequencing
  • Data Analysis

North America Long Read Sequencing Market -By End User

  • Academic Research Institutes
  • Hospitals and Clinics
  • Pharma and Biotechnology Companies

North America Long Read Sequencing Market -By Country

  • US
  • Canada
  • Mexico

North America Long Read Sequencing Market -Company Profiles

  • Bionano Genomics
  • F. HOFFMANN-LA ROCHE LTD.
  • Illumina, Inc.
  • Oxford Nanopore Technologies
  • Pacific Biosciences of California, Inc.
  • PerkinElmer, Inc.
  • Quantapore, Inc.

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Author’s Bio:

Suryakant Gadekar

Senior Market Research Expert at Business Market Insights